By Baracco L., Zaitsev D., Zampieri G.
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Extra info for A Burns-Krantz type theorem for domains with corners
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Applying MS/MS and selected reaction monitoring (SRM) eliminated the visibly interfering matrix (Fig. 9b). 2-200 ng/ml. In the case of urine, better results were obtained, as less interference of matrix was observed. 8%, with detection limits of 4-22 pg/ml. Most probably, the low extraction efficiencies in blood are not due to the equilibrium nature of the extraction as claimed by the authors. It is more likely that a co-precipitation of proteins and bound drug due to acidifcation with perchloric acid occurred.
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