Advances in Parasitology, Vol. 43 by J.R. Baker, R. Muller, D. Rollinson (Eds.)

By J.R. Baker, R. Muller, D. Rollinson (Eds.)

Advances in Parasitology is a sequence of updated stories of all components of curiosity in modern parasitology. It comprises scientific experiences on parasites of significant impact, comparable to typanosomeiasis and scabies, and extra conventional parts, equivalent to zoology, taxonomy, and existence background, which form present pondering and functions.

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Brucei suggest that a range of population structures exist in nature, each presumably with a characteristic associated level of genetic exchange. IA analysis of a population of T. 6. , 1994) suggested frequent recbmbination, while analysis of T . b. , 1994; Stevens and Tibayrenc, 1996). Thus, T. b. rhodesiense can be characterized epidemiologically by its ability to reproduce by explosive clonal reproduction in response to changes in environmental/ ecological conditions, resulting in an outbreak of disease, whilst maintaining an important underlying level of genetic exchange.

35 GENETIC EXCHANGE I N THE TRYPANOSOMATIDAE Fish & Arnphibia - T. , T. evansi & T. equiperdum T. congolense Trypanosoma 1ri" I T. simiae T . vivax T. rangeli 9 T. , 1998). 3). 36 W. GIBSON AND J. G. S. are currently supported by The Wellcome Trust. We thank S. Brisse, I. Sidibe, M . Tibayrenc, J. Haag and P. Overath for access to material before publication and M. Bailey for help with the Figures. R. M. (1991). Molecular cloning and analysis of two tandemly linked genes for pyruvate kinase of Trypanosoma brucei.

Stable, drug-resistant mutants were selected after chemical mutagenesis, mixed in culture and subsequently plated out to determine drug resistance phenotype. In two of six trials, doubly drugresistant putative hybrid colonies developed. The problem of reproducibility led the authors to a rather cautious interpretation of the results of these promising experiments. 3. 1. Introduction Approaches to the investigation of genetic exchange in natural populations of trypanosomatids are now well established.

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