Anatomy of a Scientific Discovery: The Race to Find the by Jeff Goldberg

By Jeff Goldberg

In past due 1973, scientists John Hughes and Hans Kosterlitz spent nearly all of their time in an underfunded, vague, and cramped laboratory in Aberdeen, Sweden. whereas engaged on the brains of pigs, the duo came upon a nonaddictive narcotic chemical that they was hoping to later locate in human brains. in the event that they may possibly isolate this chemical in people, might be they can have the ability to assist the realm start to heal itself. Hughes and Kosterlitz’s examine may necessarily cause them to become aware of endorphins, the body’s personal normal morphine and the chemical that makes it attainable to believe either ache and pleasure.

Announcing their findings to the clinical international thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists world wide have been swiftly interpreting the human mind and its endorphins. In many years’ time, they might use the team’s preliminary study to hyperlink endorphins to drug dependancy, runner’s excessive, urge for food regulate, sexual reaction, and psychological health problems equivalent to melancholy and schizophrenia.

In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives ahead of, in the course of, and after their ancient and medical leap forward. He additionally takes a glance on the greater photograph, revealing the brutal festival among drug businesses to discover the way to benefit from this enormous discovery.

Show description

Read or Download Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine PDF

Best methodology & statistics books

Regulators and Effectors of Small GTPases, Part F: Ras Family I

The significantly acclaimed laboratory typical for greater than forty years, equipment in Enzymology is without doubt one of the such a lot hugely revered guides within the box of biochemistry. on the grounds that 1955, each one quantity has been eagerly awaited, often consulted, and praised through researchers and reviewers alike. Now with greater than three hundred volumes (all of them nonetheless in print), the sequence comprises a lot fabric nonetheless appropriate this day, actually a necessary ebook for researchers in all fields of lifestyles sciences.

Ubiquitin and Protein Degradation, Part A

Because the inception of the sequence, every one quantity has been eagerly awaited, often consulted, and praised by way of researchers and reviewers alike. The sequence includes a lot fabric nonetheless appropriate this present day - really a vital ebook for researchers in all box of lifestyles sciences. Ubiquitin and Protein Degradation, half A will conceal excessive point purification, bioinformatics research and substrate identity of the foremost proteins focused on protein degradation.

Embryonic Stem Cell Protocols

This wide quantity explores components of extreme job on the topic of the very early dedication of stem cells to specific lineages and the development of differentiation to mature telephone levels. study on embryonic stem cells maintains to maneuver in a short time, hence the categories of reviews proceed to extend and diversify, and methodologies are consistently being sophisticated and greater, which this booklet displays.

Electron paramagnetic resonance investigations of biological systems by using spin labels, spin probes, and intrinsic metal ions. Part A

Electron Paramagnetic Resonance Investigations of organic structures by utilizing Spin Labels, Spin Probes, and Intrinsic steel Ions half A & B, are the most recent volumes within the equipment in Enzymology sequence, carrying on with the legacy of this ideal serial with caliber chapters authored via leaders within the box.

Additional info for Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine

Example text

Because the monetary rewards are minimal, they go for the ego rewards . ” By any standards, Avram Goldstein had had a highly successful career. D. D. degrees had been earned at Harvard Medical School. He was currently earning nearly $70,000 a year as chairman of the Stanford University Pharmacology Department. He and his wife, Dora (herself a respected scientist), were living in one of the expensive outlying redwooded communities of Palo Alto. ” He had chosen to devote his talents to battling an epidemic that had hit the West Coast and was spreading across the nation in the form of a massive influx of potent “China White” heroin from Southeast Asia’s Golden Triangle.

The formula was the ultimate goal, but to begin to approach that objective, fresh animal brains were needed. Hence, on cold and wet mornings in the fall of 1973, Hughes sat in the public slaughterhouse of Aberdeen amongst a pile of pig’s heads, packing away what was left of their brains into the crate on the front of his bicycle, far from scientific glory and, indeed, very much alone. ” Kosterlitz was the source. BRAIN SOUP Hans Kosterlitz’s battered Ford Anglia was parked in its usual spot near the archway in the courtyard of Marishal College when Hughes rolled in.

I thought, ‘Oh, I don’t believe it, it’s not true,’” Akil recalls. “So I did another animal, and it was the same, then another animal, and I ended up doing the whole study that evening. It was a memorable night. ” In January 1972, Liebeskind went to Paris on a one-year sabbatical, leaving Akil working to complete a more extensive study with naloxone, an even purer opiate antagonist than nalorphine. He sent her final results to the journal of the French Academy of Science, Contes Rendus, where an article on SPA coauthored by Akil and Liebeskind had appeared just one month before Akil gave her talk in San Francisco.

Download PDF sample

Rated 4.52 of 5 – based on 8 votes