By VIEN, Gerhard A. Holzapfel, Ray W. Ogden
The publication is written through best specialists within the box featuring an updated view of the subject material in a didactically sound demeanour. It provides a evaluate of the present wisdom of the behaviour of soppy tissues within the cardiovascular process below mechanical so much, and the significance of constitutive legislation in realizing the underlying mechanics is highlighted. Cells also are defined including arteries, tendons and ligaments, middle, and different organic tissues of present examine curiosity in biomechanics. This contains experimental, continuum mechanical and computational views, with the emphasis on nonlinear behaviour, and the simulation of mechanical systems reminiscent of balloon angioplasty.
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Extra info for Biomechanics of Soft Tissue in Cardiovascular Systems
The test chamber made of acrylic plates is designed with a window of glass coverslip at the bottom. It is mounted on the inverted fluorescence microscope. The temperature of a solution in the chamber can be kept at 37°C with the external circulation of heated water and with a heater placed on the stage of the microscope. The microscope is placed on a vibration isolator. 03 mm thick) and a laser displacement meter; the cantilever is housed in a small case (20 x 20 x 10 mm) and attached to an acrylic arm which is attached to a piezoelectric micromanipulator.
These results suggest that the influence of shear stress on EC mechanical stiffness is related to alterations in the cytoskeletal structure. It might be expected that at an early stage of atherosclerosis the cytoskeleton of ECs could play an important role in determining the permeability of endothelium to macromolecules, for example, via transendothelial and junctional transport. Cells in high shear regions, in response to their mechanical stress environment, would have a more highly developed cytoskeletal structure which could inhibit both transendothelial and junctional macromolecule transport.
D. 7 Indentation 6 (1-1m) Figure 26. Average force-indentation curves obtained at the highest point in endothelial cells at three locations in rabbit aortic bifurcations (Miyazaki and Hayashi (1999)). b between the three locations. There were significant differences in the parameter c among the locations by one-way ANOVA; it was higher in the medial wall than in the other two locations. These results indicate that ECs in the medial wall of the iliac artery are stiffer than those in the other sites, which may reflect the existence of abundant stress fibers in the ECs in the medial wall.