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In March 2001, the nationwide Institutes of future health issued the subsequent caution: "The variety of websites delivering health-related assets grows on a daily basis. Many websites offer invaluable details, whereas others can have details that's unreliable or deceptive. " in addition, as a result fast raise in Internet-based details, many hours may be wasted looking out, deciding upon, and printing.
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Extra info for Diabetic Retinopathy - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
In these patients there is pathologic growth of new blood vessels in the inner retina. These poorly formed blood vessels burst, bleeding into the retina and obscuring vision. Current treatment for these patients is to detect the neovascular formations and ablate tissue around the vessels, intending to reduce or eliminate further angiogenic response. It is proposed that new blood vessels are formed Studies 31 in response to local tissue hypoxia, but it is not possible at this time to identify focal areas of hypoxia in the retina.
Good evidence suggests that photoreceptor degeneration in this model occurs through apoptosis. The ability of anti-apoptotic genes expressed in transgenic mice to inhibit photic injury induced cell death will be tested. Specifically, the ability of anti-oxidant genes and antiapoptosis genes that act upstream or downstream in apoptosis pathways to inhibit photoreceptor degeneration will be evaluated. Further, the intracellular localization of cytochrome c, a mediator of apoptosis, and the role of caspase activation will be probed.
Capillary ischemia could be due at least in part to obstruction caused by abnormal or accelerated growth of vascular smooth muscle cells. The increases in angiotensin (Ang) II and insulin levels that occur in hypertension and noninsulin dependent diabetes (type 2) may contribute to this process within the small ophthalmic arteries. Thus, insulin and Ang II could act in a synergistic manner. Inhibiting the renin-angiotensin system (RAS) confers a therapeutic benefit in the treatment of diabetic retinopathy.