Taurine and the Heart: Proceedings of the Symposium Annexed by N. Sperelakis, T. Yamamoto, G. Bkaily, H. Sada, A. Sawamura

By N. Sperelakis, T. Yamamoto, G. Bkaily, H. Sada, A. Sawamura (auth.), Heitaroh Iwata, John B. Lombardini, Tomio Segawa (eds.)

The first Taurine Symposium equipped by way of Dr. Ryan Huxtable and the overdue Dr. Andre Barbeau used to be held in Tucson, Arizona, in 1975. seeing that that auspici­ ous occasion, 9 overseas symposia at the position of taurine in biology have taken position. The destinations for those conferences were Tucson (two times), Rome, Philadelphia, Tokyo, Vancouver, Mexico urban, Helsinki, and Florence. In 1977, because of the huge variety of scientists in Japan who have been attracted to the position of this particular amino acid in organic platforms, we prepared the japanese examine Society on Sulfur Amino Acids with the encouragement and monetary tips of the Taisho Pharmaceutical Co., Ltd (Tokyo). Annual conferences were held, and the club has improved from seventy eight to 414 in 1987; the variety of displays has elevated in this time span from 29 to seventy four. The symposium in Tokyo in 1982, "Sulfur Amino Acids, Biochemical and scientific elements" [1], used to be held to have a good time the fifth Annual assembly of our Society. i want to stress that during Japan we've an energetic learn Society particularly directed to the examine of sulfur amino acids. now we have released our personal semi-annual magazine entitled Sulfur Amino Acids. Our society is an inter­ disciplinary learn society because taurine is a hugely different compound that interconnects body structure, biochemistry, pharmacology, foodstuff, and drugs. One interesting fringe good thing about taurine learn and the society has been the fostering of contacts with unique scientists from many diversified scientific fields.

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Extra resources for Taurine and the Heart: Proceedings of the Symposium Annexed to the 10th Annual Meeting of the Japanese Research Society on Sulfur Amino Acids Osaka, Japan, September 10, 1987

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4. AzumaJ, Takihara K, Awata N, Ohta H, Sawamura A, Harada H, Kishimoto S. 1984. Beneficial effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits. Res Commun Chern Pathol Pharmacol 45:261-270. 5. Takihara K, AzumaJ, Awata N, Ohta H, Sawamura A, Kishimoto S, Sperelakis N. 1985. Taurine's possible protective role in age-dependent response to calcium paradox. Life Sci 37:1705-1710. 6. Takihara K, AzumaJ, Awata N, Ohta H, Hamaguchi T, Sawamura A, Tanaka Y, Kishimoto S, Sperelakis N.

4. AzumaJ, Takihara K, Awata N, Ohta H, Sawamura A, Harada H, Kishimoto S. 1984. Beneficial effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits. Res Commun Chern Pathol Pharmacol 45:261-270. 5. Takihara K, AzumaJ, Awata N, Ohta H, Sawamura A, Kishimoto S, Sperelakis N. 1985. Taurine's possible protective role in age-dependent response to calcium paradox. Life Sci 37:1705-1710. 6. Takihara K, AzumaJ, Awata N, Ohta H, Hamaguchi T, Sawamura A, Tanaka Y, Kishimoto S, Sperelakis N.

The addition of increasing concentrations of phenylephrine in the presence of 10- 6 M propranolol dose dependently increases the fluorescence of Quin-2-AM, indicating an increase in intracytoplasmic free calcium (Table 2-3). Phenylephrine also increased the aequorin signal in rabbit papillary muscle [28]. Twenty mM taurine reduced the Ca 2 + concentration at each phenylephrine concentration while ~-alanine did not alter the increase in calcium induced by a-receptor stimulation (Table 2-3). Therefore, we conclude that the effect of taurine is due to a direct interaction with cardiac myocytes.

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